Basic information about inhibitors

IPAD-DB ID	C01230
Name	3, 6, 2', 4', 5'-Pentahydroxyflavone
Category	Natural compounds
2D Structure
3D Structure
Molecular Formula	C 1 5 H 1 0 O 7
Molecular Weight	302.23 g/mol
IUPAC Name	3, 6-dihydroxy-2-(2, 4, 5-trihydroxyphenyl)chromen-4-one
InChI	InChI=1S/C15H10O7/c16-6-1-2-12-8(3-6)13(20)14(21)15(22-12)7-4-10(18)11(19)5-9(7)17/h1-5, 16-19, 21H
InChIKey	RVFIXKXGOWFZDL-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C=C1O)C(=O)C(=C(O2)C3=CC(=C(C=C3O)O)O)O
PubChem CID	24721082
DrugBank Accession Number	-
CAS Registry Number	-

Biological activity data

Ki	-
EC50	-
IC50	-
Inhibition	-
Toxicity	-
ROS(reactive oxygen species)	-
Metal Chelating	-
BBB(blood-brain barrier)	-
Target Protein	α-Syn
Effects	Inhibit aggregation of alpha-synuclein
Research Models	In BL-21 cell, in vitro, kinetic study
Main Source	Blainvillea acmella (L.) Phillipson
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Physicochemical properties

Molecular Weight(Computed by SwissADME)	302.24
Hac(Computed by SwissADME)	22
Volume(Computed by ADMETlab 2.0)	282.767
Density(Computed by ADMETlab 2.0)	1.068
nRing(Computed by ADMETlab 2.0)	3
MaxRing(Computed by ADMETlab 2.0)	10
nHet(Computed by ADMETlab 2.0)	7
fChar(Computed by ADMETlab 2.0)	0
nRig(Computed by ADMETlab 2.0)	18
Flexibility(Computed by ADMETlab 2.0)	0.056
Stero Centers(Computed by ADMETlab 2.0)	0
LogS(Computed by ADMETlab 2.0)	-3.575
LogD(Computed by ADMETlab 2.0)	1.488

ADMET properties

logP(Computed by ADMETlab 2.0)	1.784
TPSA(Computed by SwissADME)	131.36
Hbond Acceptor(Computed by SwissADME)	7
Hbond Donor(Computed by SwissADME)	5
Rotatable Bonds(Computed by SwissADME)

Pharmacokinetics

GI Absorption(Computed by SwissADME)	High
BBB(blood-brain barrier) Permeant(Computed by SwissADME)	No
P-gp Substrate(Computed by SwissADME)	No
CYP1A2 Inhibitor(Computed by SwissADME)	Yes
CYP2C19 Inhibitor(Computed by SwissADME)	No
CYP2C9 Inhibitor(Computed by SwissADME)	No
CYP2D6 Inhibitor(Computed by SwissADME)	Yes
CYP3A4 Inhibitor(Computed by SwissADME)	Yes
log Kp(Skin Permeation)(Computed by SwissADME)	-7.44

Druglikeness

Lipinski(Computed by SwissADME)	0
Ghose(Computed by SwissADME)	0
Veber(Computed by SwissADME)	0
Egan(Computed by SwissADME)	0
Muegge(Computed by SwissADME)	0
Bioavailability Score(Computed by SwissADME)	0.55