Alzheimer’s Disease (AD) is a universal neurodegenerative disease characterized by progressive dementia. Research into AD indicates that several factors play crucial roles in the pathophysiology of the disease, such as acetylcholine deficiency, β-amyloid protein deposition, tau protein phosphorylation, oxidative stress, and metal homeostasis imbalance. Currently, there are only seven FDA-approved drugs for the treatment of AD, which can only temporarily slow down the deterioration of symptoms and cannot reverse the disease process. Screening for inhibitors that can interact with proteins associated with AD plays a key role in the development of AD drugs. Huge amounts of such inhibitors are scattered in numerous published articles, which is inconvenient for researchers to explore the drug candidates for AD.

IPAD-DB is the first web-accessible database for experimentally verified inhibitors of proteins associated with Alzheimer’s Disease. The inhibitors curated in the database include natural compounds, synthetic compounds, drugs, natural extracts, and nano-inhibitors. We are committed to adding new data and improving the usability of the interface regularly. We hope that IPAD-DB can significantly contribute to the screening of AD drug candidates and the investigation into the pathogenesis of AD.