| IPAD-DB ID |
N00032 |
| Name |
EGCG microparticles (MPs) |
| Category |
Nano-inhibitors |
| EC50 |
- |
| IC50 |
- |
| Inhibition |
- |
| Toxicity |
|
| ROS(reactive oxygen species) |
The MPs reduced the cytotoxic effects of α-syn oligomers |
| Metal Chelating |
|
| BBB(blood-brain barrier) |
NO |
| Target Protein |
Alpha-synuclein |
| Effects |
(1) The MPs modestly remodeled mature amyloid fibrils and efficiently inhibited the amyloidogenic aggregation of α-syn; (2) MPs can drive amyloid fibril remodeling modestly, interacting directly with α-syn fibrils, decrease ThT fluorescence, and reduce modestly amyloid seeding competence without altering the secondary structure content; |
| Research Models |
Dopaminergic cells and microglial cells |
| Main Source |
|
| Ref. Link |
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