| IPAD-DB ID |
N00023 |
| Name |
Congo Red/Rutin-MNPs |
| Category |
Nano-inhibitors |
| EC50 |
- |
| IC50 |
- |
| Inhibition |
- |
| Toxicity |
Treatment of cells with Rutin-MNPs that had no targeted molecular Congo red reduced cytotoxicity |
| ROS(reactive oxygen species) |
The treatment of cells with Rutin-MNPs or Congo red-MNPs+Rutin diminished the levels of ROS by 48% and 50%, respectively, compared to cells exposed to Aβ+Cu 2+ |
| Metal Chelating |
Cu and Zn |
| BBB(blood-brain barrier) |
PASS |
| Target Protein |
Aβ1-42 |
| Effects |
(1) Congo red-MNPs+Rutin also increased the cell viability to about 90%; (2) Congo red/Rutin-MNPs effectively reduced the generation of NO; |
| Research Models |
G SH-SY5Y neuroblastoma cells, APPswe/PS1dE9 transgenic mice, |
| Main Source |
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| Ref. Link |
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