| IED ID | IndEnz0002018856 |
| Enzyme Type ID | protease018856 |
| Protein Name |
Rhizopuspepsin EC 3.4.23.21 |
| Gene Name | |
| Organism | Rhizopus chinensis (Bread mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Fungi incertae sedis Mucoromycota Mucoromycotina Mucoromycetes Mucorales (pin molds) Mucorineae Rhizopodaceae Rhizopus Rhizopus microsporus Rhizopus chinensis (Bread mold) |
| Enzyme Sequence | MKFTLISSCIAIAALAVAVDAAPGEKKISIPLAKNPNYKPSAKNAIQKAIAKYNKHKINTSTGGIVPDAGVGTVPMTDYGNDVEYYGQVTIGTPGKKFNLDFDTGSSDLWIASTLCTNCGSRQTKYDPKQSSTYQADGRTWSISYGDGSSASGILAKDNVNLGGLLIKGQTIELAKREAASFANGPNDGLLGLGFDTITTVRGVKTPMDNLISQGLISRPIFGVYLGKASNGGGGEYIFGGYDSTKFKGSLTTVPIDNSRGWWGITVDRATVGTSTVASSFDGILDTGTTLLILPNNVAASVARAYGASDNGDGTYTISCDTSRFKPLVFSINGASFQVSPDSLVFEEYQGQCIAGFGYGNFDFAIIGDTFLKNNYVVFNQGVPEVQIAPVAQ |
| Enzyme Length | 393 |
| Uniprot Accession Number | P06026 |
| Absorption | |
| Active Site | ACT_SITE 103; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094; ACT_SITE 286; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.; EC=3.4.23.21; |
| DNA Binding | |
| EC Number | 3.4.23.21 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Beta strand (25); Chain (1); Disulfide bond (2); Domain (1); Helix (10); Natural variant (8); Propeptide (1); Signal peptide (1); Turn (3) |
| Keywords | 3D-structure;Aspartyl protease;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (8) |
| Cross Reference PDB | 1UH7; 1UH8; 1UH9; 2APR; 3APR; 4APR; 5APR; 6APR; |
| Mapped Pubmed ID | 14501114; 1603809; 3313384; |
| Motif | |
| Gene Encoded By | |
| Mass | 41,327 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |