| IED ID | IndEnz0002003084 |
| Enzyme Type ID | protease003084 |
| Protein Name |
Putative Xaa-Pro aminopeptidase FRA1 EC 3.4.11.9 Fe repressor of activation 1 |
| Gene Name | FRA1 YLL029W |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MTSKPSTSDGRAHSISHVPGTHMRGTSASHSPRPFRPCADCTCSPGLLSRQGRRASLFLRQLENSRRSSSMLLNELKGAGGGSSAGNGSVYSCDSLCAVNREVNTTDRLLKLRQEMKKHDLCCYIVPSCDEHQSEYVSLRDQRRAFISGFSGSAGVACITRDLLNFNDDHPDGKSILSTDGRYFNQARQELDYNWTLLRQNEDPITWQEWCVREALEMAKGLGNKEGMVLKIGIDPKLITFNDYVSFRKMIDTKYDAKGKVELVPVEENLVDSIWPDFETLPERPCNDLLLLKYEFHGEEFKDKKEKLLKKLNDKASSATTGRNTFIVVALDEICWLLNLRGSDIDYNPVFFSYVAINEDETILFTNNPFNDDISEYFKINGIEVRPYEQIWEHLTKITSQASSAEHEFLIPDSASWQMVRCLNTSTNANGAIAKKMTAQNFAIIHSPIDVLKSIKNDIEIKNAHKAQVKDAVCLVQYFAWLEQQLVGREALIDEYRAAEKLTEIRKTQRNFMGNSFETISSTGSNAAIIHYSPPVENSSMIDPTKIYLCDSGSQFLEGTTDITRTIHLTKPTKEEMDNYTLVLKGGLALERLIFPENTPGFNIDAIARQFLWSRGLDYKHGTGHGIGSFLNVHEGPMGVGFRPHLMNFPLRAGNIISNEPGYYKDGEYGIRIESDMLIKKATEKGNFLKFENMTVVPYCRKLINTKLLNEEEKTQINEYHARVWRTIVHFLQPQSISYKWLKRETSPL |
| Enzyme Length | 749 |
| Uniprot Accession Number | Q07825 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.; EC=3.4.11.9; |
| DNA Binding | |
| EC Number | 3.4.11.9 |
| Enzyme Function | FUNCTION: Involved in the regulation of the iron regulon in responss to decreased mitochondrial iron-sulfur cluster synthesis. {ECO:0000269|PubMed:18281282}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Metal binding (6); Modified residue (3); Region (1) |
| Keywords | Aminopeptidase;Cytoplasm;Direct protein sequencing;Hydrolase;Manganese;Metal-binding;Metalloprotease;Phosphoprotein;Protease;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. |
| Modified Residue | MOD_RES 69; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19779198"; MOD_RES 92; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19779198"; MOD_RES 95; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198" |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10487931; 11805837; 11921089; 12140549; 14690591; 15766533; 16554755; 17107617; 17651441; 19536198; 19715344; 20139087; 20522543; 20702584; 21479832; 21840721; 22389494; 22583368; 23457300; 23595675; 23962819; 27693354; |
| Motif | |
| Gene Encoded By | |
| Mass | 84,924 |
| Kinetics | |
| Metal Binding | METAL 551; /note=Manganese 2; /evidence=ECO:0000255; METAL 562; /note=Manganese 1; /evidence=ECO:0000255; METAL 562; /note=Manganese 2; /evidence=ECO:0000255; METAL 660; /note=Manganese 1; /evidence=ECO:0000255; METAL 674; /note=Manganese 1; /evidence=ECO:0000255; METAL 674; /note=Manganese 2; /evidence=ECO:0000255 |
| Rhea ID | |
| Cross Reference Brenda |