| IED ID | IndEnz0002002639 |
| Enzyme Type ID | protease002639 |
| Protein Name |
Serine protease Lpg1137 EC 3.4.22.- |
| Gene Name | lpg1137 |
| Organism | Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Legionellales Legionellaceae Legionella Legionella pneumophila Legionella pneumophila subsp. pneumophila Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) |
| Enzyme Sequence | MIQRGFTMQERREKQGNNSPYLLTPYEMANLVFKTGAISFTVSAGTQPFQYLLNKLQFSQSGTPSGLSGGLFRGMYRGFLPYAIAGQKRGAVAVTHKQTNKVTEEEEFEAPFRQRWWGTIFFSQADLLVSNGLSGKARLQNVGVINAENFKWSLSNFWKLTSVNWGSRSFAGGVNFALIGFAGDYVSSFYKFDKDLYNKILGGATSGVIATLFTTAPNAYADSKLLQTKVAENNRLITVSPYTMFGQMKSHVKAVGLKEAFMTFFKVSYLQQVAVRAPQAAITFALIFGMDEYMGPQPLKKVWPGRVEELESENPSPSPTKK |
| Enzyme Length | 322 |
| Uniprot Accession Number | Q5ZWE8 |
| Absorption | |
| Active Site | ACT_SITE 68; /evidence=ECO:0000305|PubMed:28504273 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Serine protease effector that inhibits host cell autophagy by targeting SNX17 (PubMed:28504273). Localizes to the host endoplasmic reticulum-mitochondria contact site and catalyzes degradation of host SNX17, thereby impairing endoplasmic reticulum-mitochondria communication, leading to inhibit autophagy as well as staurosporine-induced apoptosis (PubMed:28504273). {ECO:0000269|PubMed:28504273}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Mutagenesis (2) |
| Keywords | Host membrane;Host mitochondrion;Hydrolase;Membrane;Protease;Reference proteome;Secreted;Serine protease;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:28504273}. Host mitochondrion membrane {ECO:0000269|PubMed:28504273}. Note=Localizes to the host mitochondria-associated endoplasmic reticulum membrane (MAM). {ECO:0000269|PubMed:28504273}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 35,793 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |