| IED ID | IndEnz0002002297 |
| Enzyme Type ID | protease002297 |
| Protein Name |
RNA-directed RNA polymerase L Protein L EC 2.7.7.48 Large structural protein Replicase Transcriptase |
| Gene Name | L |
| Organism | Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV) |
| Taxonomic Lineage | Viruses Riboviria Orthornavirae Negarnaviricota Polyploviricotina Ellioviricetes Bunyavirales Peribunyaviridae Orthobunyavirus Schmallenberg orthobunyavirus Schmallenberg virus (SBV) Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV) |
| Enzyme Sequence | METYKINIFRDRINQCRSAEEAKDIVADLLMARHDYFGREVCYYLDIEFRQDVPAYDILLEFLPAGTAFNIRNCTPDNFIIHNGKLYIIDYKVSTDHAYGQKTYEKYTQIFGDALSELPFDFEVVIIRADPLRDTIHVNSNQFLEIFGPLNINLDFTWFFNLRSLIYEKYKDDDRFLEIVNQGEFTMTGPWIDEDTPELYSHPVFLEFYDSLDEMAKLTFHESMTFDATRGEKWNQNLQKVINRYGNDYNIFVKEAAAGIFRCEGNYPKPNHDEITIGWNQMVQRVSTERNLTQDVSKQKPSIHFIWGQPDETSNATTPKLIKIAKALQNISGESTYISAFRALGMLMDFSENTALYEAHTSKLKSMARQTSKRIDTKLEPIKIGTATIYWEQQFKLDTEIMNTKDKSHLLKDFLGIGGHVQFSKKTIDDLDTDKPTILDFNKKEVIDFCKFQYENVKKILSGDNNLERIGCYLEEYGANIASCSKDTWDQINQIGKSNYWACIKDFSVLMKNMLAVSQYNRHNTFRVVCCANNNLFGFVMPSSDIKAKRSTLVYFLAVLHSTPQNVMHHGALHATFKTGSKYLSISKGMRLDKERCQRIVSSPGLFMLTTLMFAGDNPTLNLTDVMNFTFHTSLSITKAMLSLTEPSRYMIMNSLAISSHVRDYIAEKFGPYTKTSFSVVMANLIKRGCYMAYNQRDKVDMRNICLTDYEITQKGVRDNRDLSSIWFEGYVSLKEYINQIYLPFYFNSKGLHEKHHVMIDLAKTILDIERDQRLNIPGIWSTTPRKQTANLNITIYAVAKNLIMDTARHNYIRSRIENTNNLNRSICTISTFTSSKSCIKVGDFEKEKSSATKKAADCMSKEIKKYTIANPEFVDEELLNATIRHSRYEDLKKAIPNYIDIMSTKVFDSLYQKIKRKEIDDKPTVYHILSAMKNHTDFKFTFFNKGQKTAKDREIFVGEFEAKMCLYLVERISKERCKLNPDEMISEPGDSKLKKLEELAESEIRFTAATMKQIKERYLAEMGEASHMIAYKPHSVKIEINADMSKWSAQDVLFKYFWLFALDPALYLQEKERILYFLCNYMQKKLILPDEMLCSILDQRIKHEDDIIYEMTNGLSQNWVNIKRNWLQGNLNYTSSYLHSCSMNVYKDILKRAATLLEGEVLVNSMVHSDDNHTSIVMIQDKLDDDIVIEFSAKLFEKICLTFGNQANMKKTYITNFIKEFVSLFNIYGEPFSVYGRFILTSVGDCAFLGPYEDVASRLSATQTAIKHGAPPSLAWTAIALTQWITHSTYNMLPGQINDPTSSLPSHDRFELPIELCGLINSELPTIAIAGLEADNLSYLVRLSKRMSPIHLCREPIQHQYENIHTWDISKLTQCDIFRLKLLRYMTLDSTMSSDDGMGETSEMRSRSLLTPRKFTTASSLSRLHSYADYQKTIQDQQKIEELFEYFIANPQLLVTKGETCEEFCMSVLFRYNSRKFKESLSIQNPAQLFIEQVLFANKPMIDYTSIHDRLFGIQDDPNINDATCIIGKKTFVETYQQIKIDVEKFTLDVEDIKTIYSFCIMNDPILVACANNLLISIQGVEMQRLGMTCCYMPEIKSLKVIYHSPALVLRAYVTDNYEQKGMEPDEMRRDIYHLEEFIEKTKLRTNMQGRIANNEIKLMKRDLKFEVQELTKFYQICYEYVKSTEHKIKIFILPKKAYTPIDFCSLVTGNLISDNKWMVVHYLKQITVPAKKAQIATSIDLEIQIAYECFRLIAHFADMFLNDDSKKAYINAIINTYTYKDVQVSSLYKKIKNSRLRSKIIPLLYHLGDLQQIDVDRFDAEKAEEQITWNNWQTSREFTTGPIDLSIKGYGRSIRIVGEDNKLTAAEMQLSRVRSDIVSRHGQALLNKPHGLKLEKMEPVTDLNPKLWYIAYQLREKKRYHYGVFSTSYIEEHNSRIEASRIRKTNKWIPVCPIAISKQSSDGKPSLAKIPMLNIGEIKFTKLQIAVDDHAMIRKAPFSKMVFFDGPPIQSGGIDIGKLMKNQNILNLRLDNIQSITLLDLCRIFSCRGSKVDQDAFEFLSDEPLDEDVIDELDSSPALVVSYTKKSTKSNSFKNVIVRALIRECDIFEDIMDITDDGFTSDSNLEVLENLTWILNMLATNQWSTELLACIHMCLYRNEMDHIYHNFQVPEIFVDNPISLNVKWDEVIMFLNILRDRDYKFEPWVSILNHSLTKAIEYAYKKMEEERKQKSTGINKFLKGKKMGGRSKFDFQ |
| Enzyme Length | 2254 |
| Uniprot Accession Number | H2AM11 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539}; |
| DNA Binding | |
| EC Number | 2.7.7.48 |
| Enzyme Function | FUNCTION: RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1) |
| Keywords | Hydrolase;Nucleotide-binding;Nucleotidyltransferase;Protease;RNA-directed RNA polymerase;Thiol protease;Transferase;Ubl conjugation pathway;Viral RNA replication;Virion |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Virion {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 261,027 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:21248 |
| Cross Reference Brenda |