| IED ID | IndEnz0002001969 |
| Enzyme Type ID | protease001969 |
| Protein Name |
Thermitase EC 3.4.21.66 |
| Gene Name | |
| Organism | Thermoactinomyces vulgaris |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Thermoactinomycetaceae Thermoactinomyces Thermoactinomyces vulgaris |
| Enzyme Sequence | YTPNDPYFSSRQYGPQKIQAPQAWDIAEGSGAKIAIVDTGVQSNHPDLAGKVVGGWDFVDNDSTPQNGNGHGTHCAGIAAAVTNNSTGIAGTAPKASILAVRVLDNSGSGTWTAVANGITYAADQGAKVISLSLGGTVGNSGLQQAVNYAWNKGSVVVAAAGNAGNTAPNYPAYYSNAIAVASTDQNDNKSSFSTYGSVVDVAAPGSWIYSTYPTSTYASLSGTSMATPHVAGVAGLLASQGRSASNIRAAIENTADKISGTGTYWAKGRVNAYKAVQY |
| Enzyme Length | 279 |
| Uniprot Accession Number | P04072 |
| Absorption | |
| Active Site | ACT_SITE 38; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 71; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 225; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins, including collagen.; EC=3.4.21.66; |
| DNA Binding | |
| EC Number | 3.4.21.66 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (16); Chain (1); Domain (1); Helix (9); Metal binding (11); Turn (6) |
| Keywords | 3D-structure;Calcium;Direct protein sequencing;Hydrolase;Metal-binding;Protease;Secreted;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 1TEC; 1THM; 2TEC; 3TEC; |
| Mapped Pubmed ID | 2688688; |
| Motif | |
| Gene Encoded By | |
| Mass | 28,366 |
| Kinetics | |
| Metal Binding | METAL 5; /note=Calcium 1; METAL 47; /note=Calcium 1; METAL 57; /note=Calcium 2; METAL 60; /note=Calcium 2; METAL 62; /note=Calcium 2; METAL 64; /note=Calcium 2; METAL 66; /note=Calcium 2; METAL 82; /note=Calcium 1; via carbonyl oxygen; METAL 85; /note=Calcium 1; METAL 87; /note=Calcium 1; via carbonyl oxygen; METAL 89; /note=Calcium 1; via carbonyl oxygen |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.66; |