| IED ID | IndEnz0002001841 |
| Enzyme Type ID | protease001841 |
| Protein Name |
Peptidyl-Lys metalloendopeptidase MEP EC 3.4.24.20 AmMEP |
| Gene Name | MEP |
| Organism | Armillaria mellea (Shoestring root rot fungus) (Honey mushroom) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetidae Agaricales Physalacriaceae Armillaria Armillaria mellea (Shoestring root rot fungus) (Honey mushroom) |
| Enzyme Sequence | MFSLSSRFFLYSLCLSAVAVSAAPGLSLSLSGADSVVDVENLNVAATLTNTGDTTLKILNDPSSILSSKFATHTFDISSDNGSPAFTGVKVKYDPNYVVKKNADSSFTVLAPGESVTVNHALGAAYNFTGSGAASYSIEPSSLFYYVDPDTNELASINADTQQHTTKISGTLAVARRSNLGKRISYNGCTSSRQTTLVSAAAAAQTYAQSSYNYLSSHTASTTRYVTWFGPYTSARHSTVLSCFSNMLAYPYANYEYDCTCTESDVYAYVYPSQFGTIYLCGAFWQTTTTGTDSRGGTLIHESSHFTIICGTQDYAYGQSAAKSLASSNPSEAIKNADNYEYFAENNPAQS |
| Enzyme Length | 351 |
| Uniprot Accession Number | Q9Y7F7 |
| Absorption | |
| Active Site | ACT_SITE 302; /evidence=ECO:0000250|UniProtKB:P81054 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by chelating agents such as imidazole, alpha,alpha'-bipyridine, and 1,10-phenanthroline. {ECO:0000269|PubMed:23849}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage in proteins: -Xaa-|-Lys- (in which Xaa may be Pro).; EC=3.4.24.20; |
| DNA Binding | |
| EC Number | 3.4.24.20 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7-7.5. Active from pH 5.25 to pH 9. {ECO:0000269|PubMed:23849}; |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (2); Metal binding (3); Propeptide (1); Sequence conflict (2); Signal peptide (1); Site (1) |
| Keywords | Cleavage on pair of basic residues;Direct protein sequencing;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Binds strongly to beta-1,3-glucan and chitin, major polysaccharides constituting the fungal cell wall. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 37,551 |
| Kinetics | |
| Metal Binding | METAL 301; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P81054; METAL 305; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P81054; METAL 314; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P81054 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.20; |