| IED ID |
IndEnz0002001765 |
| Enzyme Type ID |
protease001765 |
| Protein Name |
Stage V sporulation protein M
|
| Gene Name |
spoVM BSU15810 |
| Organism |
Bacillus subtilis (strain 168) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Terrabacteria group
Firmicutes
Bacilli
Bacillales
Bacillaceae
Bacillus
Bacillus subtilis group
Bacillus subtilis
Bacillus subtilis subsp. subtilis
Bacillus subtilis (strain 168)
|
| Enzyme Sequence |
MKFYTIKLPKFLGGIVRAMLGSFRKD |
| Enzyme Length |
26 |
| Uniprot Accession Number |
P37817 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Coordinates cortex and coat assembly during sporulation (PubMed:22463703, PubMed:8231808). Associates with the spore coat protein SpoIVA and with the outer forespore membrane, thereby serving as a membrane anchor that tethers SpoIVA and the entire spore coat to the forespore surface (PubMed:17427285). May also serve as a competitive inhibitor of FtsH activity during sporulation (PubMed:9287010). {ECO:0000269|PubMed:17427285, ECO:0000269|PubMed:22463703, ECO:0000269|PubMed:8231808, ECO:0000269|PubMed:9287010}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Helix (1); Mutagenesis (11); Region (1) |
| Keywords |
3D-structure;Membrane;Reference proteome;Sporulation |
| Interact With |
|
| Induction |
INDUCTION: Expressed during sporulation and is regulated by the mother cell-specific transcription factors sigma E and SpoIIID (PubMed:8231808). There is a lag-phase of approximately 2 hours between the onset of transcription and translation (PubMed:18820968). The 5' untranslated region negatively influences its own translation (PubMed:18820968). {ECO:0000269|PubMed:18820968, ECO:0000269|PubMed:8231808}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Forespore outer membrane {ECO:0000269|PubMed:12562810, ECO:0000269|PubMed:17427285, ECO:0000269|PubMed:22463703, ECO:0000269|PubMed:25825747, ECO:0000269|PubMed:29102609}; Peripheral membrane protein {ECO:0000269|PubMed:12562810, ECO:0000269|PubMed:17427285, ECO:0000269|PubMed:25825747}. Note=SpoVM is an atypical amphipathic alpha-helix deeply embedded in the membrane (PubMed:25825747). Proper localization depends on SpoIVA (PubMed:17427285). {ECO:0000269|PubMed:17427285, ECO:0000269|PubMed:25825747}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
NMR spectroscopy (2) |
| Cross Reference PDB |
2MVH;
2MVJ;
|
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
|
| Mass |
3,018 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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